What is the old age?
Oldness - It is a biological gradual part of the human body and systems
The aging process explores gerontology Science, which not only investigates physiological changes, but also the place of elderly people in society. The purpose of the research of gerontology is to overcome the potential shortcomings associated with aging.
Natural (endogenous, inner, physiological, chronological) aging - Natural, biological process, which is determined by internal factors and accompanied by typical age lesions.
Endogenous aging actually depends on one factor - the information that is protected by the DNA.
Endogenous factors: intoxication, impaired metabolism, impaired regulation, immune balance, heredity.
Progime aging can result in genetic (endogenous), and external (exogenous) factors (Solar radiation, wind, indoor dryness, air contamination, gadžetų radiation, pathogenic bacteria, viruses, ksenobiotics penetration, mechanical damage, smoking, occupational harmfulness (chemical, toxic, carcinogens).
Modern man Operating Risk Factors:
- biological (viruses, bacteria, parasites);
- chemical (polyutantai (air pollutants), preservatives, heavy metals, antibiotics, nitrates, plastic, biochemistry, poor cosmetics, smoking, intestinal endotoxins);
- physical (noise, vibration, ultrasonic, infragar, thermal, ionizing, non-ionizing and other radiation);
- Social (lack of sleep, impaired work and rest mode, poor water);
- climatic (sudden temperature variation, cold).
Classification of the most important aging theories and literature sources by integration level
(Yin, Chen, 2005)
- The body level
Wear Theory - Sacher, 1966
Error catastrophe theory - Orgel, 1963
Infringements of stress theory - Stlye, 1970
Autoointoxication Theory - Metnchoff, 1904
Evolution Theory (programmed aging theory) - Wiliams, 1957
Information preservation theory (programmed aging theory)
- Organ level
Endocrine Theory - Korenchevsky, 1961
Immunological Theory - Walford, 1969
The suppression of the brain
- Cell level
Cell membrane theory - ZG-Nagy, 1978
Theory of Somatic Mutations - Szillard, 1959
Mitochondrial theory - Miquel et al., 1980
Mitochondrial-Lizosoma Theory - Brunk, Terman, 2002
Cell Proliferation Limit Theory (Programmed Aging Theory) - Hayflick, Moorhead, 1961
- Level of molecules
DNA Damage Accumulation Theory - Vilenchik, 1970
Trace elements theory - Eichhorn, 1979
Free Radical Theory - Harman, 1956
Cross stitches theory - Bjorksten, 1968
Oxidative stress theory - Sohal, Allen, 1990; Yu, Yang, 1996
Non-gense Glycosylation Theory - Cerami, 1985
Carbon intoxication Theory - Yin, Brunk, 1995.