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What is the old age?

 Oldness - It is a biological gradual part of the human body and systems

the process of degradation and its consequences.Oldness - The weakening of the mechanisms of the adaptation organism, the decline in their reserves.

The aging process explores gerontology Science, which not only investigates physiological changes, but also the place of elderly people in society. The purpose of the research of gerontology is to overcome the potential shortcomings associated with aging.

Natural (endogenous, inner, physiological, chronological) aging - Natural, biological process, which is determined by internal factors and accompanied by typical age lesions.

Endogenous aging actually depends on one factor - the information that is protected by the DNA.

Endogenous factors: intoxication, impaired metabolism, impaired regulation, immune balance, heredity.

Progime aging can result in genetic (endogenous), and external (exogenous) factors (Solar radiation, wind, indoor dryness, air contamination, gadžetų radiation, pathogenic bacteria, viruses, ksenobiotics penetration, mechanical damage, smoking, occupational harmfulness (chemical, toxic, carcinogens).

Modern man Operating Risk Factors:

  • biological (viruses, bacteria, parasites);
  • chemical (polyutantai (air pollutants), preservatives, heavy metals, antibiotics, nitrates, plastic, biochemistry, poor cosmetics, smoking, intestinal endotoxins);
  • physical (noise, vibration, ultrasonic, infragar, thermal, ionizing, non-ionizing and other radiation);
  • Social (lack of sleep, impaired work and rest mode, poor water);
  • climatic (sudden temperature variation, cold).



Classification of the most important aging theories and literature sources by integration level

(Yin, Chen, 2005)

  • The body level

Wear Theory - Sacher, 1966

Error catastrophe theory - Orgel, 1963

Infringements of stress theory - Stlye, 1970

Autoointoxication Theory - Metnchoff, 1904

Evolution Theory (programmed aging theory) - Wiliams, 1957

Information preservation theory (programmed aging theory)

  • Organ level

Endocrine Theory - Korenchevsky, 1961

Immunological Theory - Walford, 1969

The suppression of the brain

  • Cell level

Cell membrane theory - ZG-Nagy, 1978

Theory of Somatic Mutations - Szillard, 1959

Mitochondrial theory - Miquel et al., 1980

Mitochondrial-Lizosoma Theory - Brunk, Terman, 2002

Cell Proliferation Limit Theory (Programmed Aging Theory) - Hayflick, Moorhead, 1961

  • Level of molecules

DNA Damage Accumulation Theory - Vilenchik, 1970

Trace elements theory - Eichhorn, 1979

Free Radical Theory - Harman, 1956

Cross stitches theory - Bjorksten, 1968

Oxidative stress theory - Sohal, Allen, 1990; Yu, Yang, 1996

Non-gense Glycosylation Theory - Cerami, 1985

Carbon intoxication Theory - Yin, Brunk, 1995.


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